Pilot 2:
Multi-Site Functional Validation of
Organ-on-Chip Models
“By validating Organ-on-Chip systems across multiple sites and compounds, we are building the reproducibility data needed to qualify these technologies as NAMs for industrial use.”
3R-Center for in vitro models and animal testing alternatives
About the pilot
- Standardises protocols to minimise inter-site variability
- Assesses basic functionality and long-term stability of OoC models in three key phases across a minimum of three sites
- Evaluates dose–response using six well-characterized compounds
- Validates predictive accuracy with six blinded compounds
Objective
Demonstrate stability, reproducibility and predictive value of OoC systems; generate best practices for broader adoption
Participation
- Benchmark your technology Have your OoC systems independently tested for stability, reproducibility, and predictive power
- Demonstrate technology readiness Generate robust, multi-site data to support regulatory acceptance and customer confidence
- Boost your market position Use independent validation results as a strong selling point in marketing and investor communications
Target group: Pharmaceutical and biotechnology companies / SMEs with prior OoC experience, either as end users conducting in-house testing or as technology providers submitting NAMs and participating to standardized testing.
About the pilot lead
The 3R-Center Tübingen connects research, policy, education and public outreach to advance human-relevant in vitro models and reduce animal testing. Working closely with regulators, decision-makers and end users of NAMs, the center develops and qualifies Organ-on-Chip systems in collaboration with the μOrganoLab for applications in basic research, pharma, personalized medicine and toxicology. It also provides tailored training to support adoption and knowledge exchange.
For more information, click here: 3R Center Tübingen
If you have any questions, don't hesitate to contact us